High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential

High-density lipoproteins and endothelial function.

Elevated plasma levels of HDL cholesterol or apolipoprotein A-I, the major protein moiety of HDL particles, are protective against coronary artery disease. HDL particles remove cholesterol from peripheral cells and transfer it to the liver for bile acid synthesis. The interaction between lipoproteins is not mediated through simple contact between 2 phospholipid membranes but involves specific p...

Plasma high density lipoproteins. Metabolism and relationship to atherogenesis.

High-density lipoproteins: a new potential therapeutic target for the prevention of cardiovascular disease.

Epidemiological studies have identified low-density lipoproteins (LDL) and high-density lipoproteins (HDL) as independent risk factors that modulate cardiovascular disease (CVD) risk.1,2 Over the past decade, clinical trials of LDL-lowering drugs have clearly established that reductions in LDL are associated with a 30% to 45% reduction in clinical events.3–7 However, despite lowered LDL, many p...

Metabolism of high-density lipoproteins in cultured rat luteal cells.

The uptake of cholesterol from high-density lipoproteins (HDL) labeled with 125I and [3H]cholesterol was examined in cultured rat luteal cells. Luteal cells were incubated with labeled HDL, following which the metabolic fate of the apolipoproteins and cholesterol moieties of the receptor-bound HDL were examined. About 50% of the originally bound HDL apolipoproteins were released into the medium...

Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function

High-density lipoprotein (HDL) levels are an inverse risk factor for cardiovascular diseases, and sphingomyelin (SM) is the second most abundant phospholipid component and the major sphingolipid in HDL. Considering the marked presence of SM, the present review has focused on the current knowledge about this phospholipid by addressing its variable distribution among HDL lipoparticles, how they a...